The game features voice actors Roy Conrad and Mark Hamill.
65daysofstatic used an audio clip from the game for their song "Asphalt and Trouble", whose title is derived from said audio.
In spring 2000, LucasArts began production of Full Throttle: Payback, an official sequel to continue the storyline of Full Throttle. LucasArts never released an official statement regarding the game cancellation.
In mid-2002, LucasArts announced Full Throttle: Hell on Wheels for Windows and, for the first time in the series, PlayStation 2 and Xbox. The development progressed smoothly until late 2003, when it was abruptly canceled.