Keyword: science fiction, sorted by popularity

Time travel, space wars, alien empires, alternate universe, cyberpunk anti-heroes, space invaders, post-apocalyptic worlds, dystopian societies, mad scientists, galaxies far far away, strange new worlds, mech battles, deep space exploration, evil robots... should I go on?

Games found: 496.

Dune 2000

Windows XP/98/951998 Westwood Studios 4.1
Doom

DOS1993protected id software 4.1
Master of Orion 2: Battle at Antares

DOS, Windows XP/98/951996protected SimTex 4.2
Command & Conquer: Red Alert

DOS1996freeware Westwood Studios 4.1
Dune

DOS1992 Cryo Interactive Entertainment 4.1
X-COM: Ufo Defense

DOS1994protected MicroProse Software 4.2
Star Wars: Yoda Stories

Windows XP/98/951997 LucasArts Entertainment Company 3.8
Albion

DOS1996 Blue Byte Software 4.1
Fallout

DOS, Windows XP/98/951997protected Interplay Productions 4.1
Duke Nukem 3D

DOS1996protected 3d Realms 4.1
Dune II: The building of a dynasty

DOS1992 Westwood Studios 4.1
Command & Conquer

DOS1995freeware Westwood Studios 3.8
Speedball 2

DOS1992 Bitmap Brothers 4
Blade Runner

Windows XP/98/951997protected Westwood Studios 4
Arkanoid

DOS1988 Taito 4
The Lost Vikings

DOS1993 Silicon & Synapse 4.2
Doom 2: Hell on Earth

DOS, Windows XP/98/951994protected id software 4.1
Frontier: Elite 2

DOS1993 Frontier Developments 4.1
Space Quest 1: The Sarien Encounter

DOS1986 Sierra On-Line 4.1
Day of the Tentacle

DOS1993protected LucasArts Entertainment Company 4
Quake

DOS, Windows XP/98/951996protected id software 4
Star Control 2

DOS1992 Toys for Bob 4
Maniac Mansion

DOS1987protected LucasArts Entertainment Company 4.1
Tyrian 2000

DOS1999freeware Eclipse Software 4.2
Star Trek: 25th Anniversary

DOS1992 Interplay Productions 4.1
Volfied

DOS1991 Taito 4.1
Alpha Centauri

Windows XP/98/951999protected Firaxis Games 3.9
Arcanum: of Steamworks and Magick Obscura

DOS2001protected Troika Games 3.9
The Hitchhiker's Guide to the Galaxy

DOS1984freeware Infocom 4
Wing Commander

DOS1990freeware Origin Systems 3.9