Games involving detective work, murder mysteries, etc.

A murder to solve! A criminal to apprehend! Detective and mistery games have the recipe for a perfect crime story. Police investigations, finding clues, mysterious killings, a noir atmosphere are all ingredients that makes a good detective / mystery game worth playing. The Police Quest series, the Tex Murphy series, games based on Sherlock Holmes are just some of the most popular detective games ever published in the last century.

Most popular detective, mystery games

Police Quest 1: In Pursuit of the Death Angel

adventureDOS

Blade Runner

adventureWindows XP/98/95, Linux

Police Quest 3: The Kindred

adventureDOS

Detective, mystery games

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221B Baker Street

DOS19863.9/5 Datasoft

221B Baker Street is a turn-based strategy strategy game developed by Datasoft. 221B Baker Street is base on the tabletop game of the same name "221B Baker Street" and it plays in a very similar way, with dices, etc.
Amnesia

DOS19864/5 Cognetics corporation
Anachronox

Windows XP/98/952001protected4.1/5 Ion Storm
Ballyhoo

DOS19863.5/5 Infocom
Blackstar: Agent of Justice

DOS19953.3/5
Blade Runner

Windows XP/98/95Linux1997protected4.2/5 Westwood Studios

Blade Runner is one of those point & click adventure games that somewhat manages to fully capture the spirit of a cult movie without copying the original plot. Fans of the Blade Runner movie will enjoy this game, even without Harrison Ford.
Blue Force

DOS19934.2/5 Tsunami Media
Borrowed Time

DOS19853.7/5 Interplay Productions
Circuit's Edge

DOS19904/5 Westwood Studios

Circuit's Edge is a single-player science fiction blend of adventure game and RPG, developed by Westwood Studios and released by Infocom in 1990. Circuit's Edge is based on George Alec Effinger's cyberpunk novel "When Gravity Fails".
Clue Master Detective

DOS19894.5/5 Dalali Software

Clue Master Detective is an abandoned strategy game developed by Dalali Software and released by Leisure Genius in 1989 for DOS, Amiga, Apple II, Atari ST, C64. Clue Master Detective is based on the well known board game Clue (also known as Cluedo). Clue can be played in single player, but the best gaming experience come from the multi-player mode.
Corruption

DOS19884/5 Magnetic Scrolls
Crime City

DOS19934/5
Cruise for a Corpse

DOS19913.9/5 Delphine software
Daughter of Serpents

DOS19924/5 Eldritch Games
Deadline

DOS19823.8/5 Infocom
Defender of Boston: The Rock Island Mystery

DOS19923.2/5
Deja Vu 2: Lost in Las Vegas

DOS19904.1/5 ICOM Simulations
Deja Vu: A Nightmare Comes True

DOS19874/5 ICOM Simulations
Eagle Eye Mysteries in London

DOS19944/5 Stormfront Studios
Eagle Eye Mysteries: The Original

DOS19933.8/5 Stormfront Studios
Earthly delights

DOS19843.6/5 Datamost
Escape from delirium

DOS19954/5 Virtual X-Perience
Fascination

DOS1991NSFW3.9/5 Coktel Vision
Fish!

DOS19883.8/5 Magnetic Scrolls
Gumboots Australia

DOS19903.7/5 Reckon Software
Hugo 2: Whodunit?

DOS1991protected3.5/5 Gray Design Associates
Igor Objective Uuklaonia

DOS19953.5/5 Péndulo Studios
In the Dead of Night

DOS19953.6/5 Trecision
Jack the Ripper

DOS19954/5 Intergalactic Development
James Bond 007: A View to a Kill

DOS19853.9/5 Angelsoft