Science fiction games

Time travel, space wars, alien empires, alternate universe, cyberpunk anti-heroes, space invaders, post-apocalyptic worlds, dystopian societies, mad scientists, galaxies far far away, strange new worlds, mech battles, deep space exploration, evil robots... should I go on?

Most popular science fiction games

Dune 2000

strategyWindows XP/98/95

Mega Man X4

shooterWindows XP/98/95

Star Wars: Yoda Stories

action-adventureWindows XP/98/95

Science fiction games

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It Came from the Desert

DOS1990freeware4.1/5 Cinemaware

It Came from the Desert is an abandonware action-adventure game developed by Cinemaware and released in 1990 for PC (DOS) and Amiga. It Came From the Desert is an action-adventure game with a peculiar flavor: it's set in the 50s, in the USA, and it's based on those old monster movies like Them! (also involving killer ants).
Janitor Joe

DOS19843/5
Jazz Jackrabbit

DOS1994protected3.8/5 Epic MegaGames
Jazz Jackrabbit Holiday Hare

DOS1994protected3.9/5 Epic MegaGames
Jetpack

DOS1993freeware4/5
Jetpack: Christmas Special

DOS19934/5
Journey to the Center of the Earth

DOS19883.4/5 Chip
Jurassic Park

DOS19934.1/5 Ocean Software
Kaeon

DOS19923.4/5
Krazy Ivan

Windows XP/98/9519963.6/5 Psygnosis
Kronolog: The Nazi Paradox

DOS19933.6/5 Castleworks Gameware
L'Eternauta: Gli Invasori della Città Eterna

DOS19942.9/5 Holodream Software
Lane Mastodon vs. the Blubbermen

DOS19884.2/5 Tom Snyder Productions
Laser Squad

DOS19924/5 Target Games Limited

Laser Squad is an abandoned turn-based strategy/tactical game designed by Julian Gollop (the mind behind the X-COM series). Laser Squad was developed by Target Games Limited and released by MicroLeague Multimedia in 1992 for DOS and other 8-bit systems. Laser Squad is considered as a precursor of X-COM: Ufo Defense.
Last Duel: Inter Planet War 2012

DOS19893.4/5 Capcom
Leather Goddesses of Phobos

DOS19864.2/5 Infocom
Leather Goddesses of Phobos 2

DOS19923.9/5 Infocom
Lexi-Cross

DOS19913.9/5 Platinumware

Lexi-Cross is an abandoned science fiction tv show-styled puzzle game. Lexi-Cross was developed by Platinumware and released for DOS by Interplay Productions in 1991. The gameplay is a turn-based mix between Scrabble and Wheel of fortune with elements of Battleship.
Lightspeed

DOS19903/5 MicroProse Software
LineWars

DOS19904.2/5 Safari Software
LineWars 2

DOS19944.2/5 Safari Software
Little Big Adventure

DOS1994protected4.2/5 Adeline Software International
Little Big Adventure 2 (Twinsen's Odyssey)

DOSWindows XP/98/951997protected3.8/5 Adeline Software International
Lode Runner

DOSMac19834.2/5 Broderbund
Lorna

DOS19903.9/5 Topo Soft
Lost in Time

DOS19934/5 Coktel Vision
Mach 3

DOS19873/5 Loriciels
Magnetic Scrolls Collection

DOS19914/5 Magnetic Scrolls

Magnetic Scrolls was one of the finest developer companies dedicated to Interactive Fiction. The Magnetic Scrolls Collection is a trilogy of Magnenic Scrolls adventures remade using the Wonderland engine: Fish!, Corruption, The Guild of Thieves. The new window-based interface made text-adventuring easy even for gamers not used to a text-only interf...
Major Stryker

DOSWindows XP/98/951993freeware3.7/5 Apogee Software
Manhunter 2: San Francisco

DOSMac19893.9/5 Evryware